Multiple Causes of Dementia as Engineered Senescence
نویسندگان
چکیده
منابع مشابه
The Lcn2-engineered HEK-293 cells show senescence under stressful condition
Objective(s): Lipocalin2 (Lcn2) gene is highly expressed in response to various types of cellular stresses. The precise role of Lcn2 has not been fully understood yet. However, it plays a key role in controlling vital cellular processes such as proliferation, apoptosis and metabolism. Recently it was shown that Lcn2 decreases senescence and increases proliferation of mesenchymal stem cells (MSC...
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how to cite this article: schulz a, kohlschütter a. ncl disorders: frequent causes of childhood dementia. iran j child neurol. 2013 winter;7(1):1-8. abstract dementia in children or young adults is most frequently caused by neuronal ceroidlipofuscinoses (ncl), a group of incurable lysosomal storage disorders linked by the accumulation of a characteristic intracellular storage material and progr...
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INTRODUCTION Although there is evidence for distinct behavioural sub-phenotypes in Alzheimer's disease (AD), their inter-relationships and the effect of clinical variables on their expression have been little investigated. METHODS We have analysed a sample of 1850 probable AD patients from the UK and Greece with 10 item Neuropsychiatric Inventory (NPI) data. We applied a Multiple Indicators M...
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A group of neurodegenerative diseases is outlined that affect cortical and subcortical areas of the brain. These diseases give rise to atypical forms of dementia and, unlike Alzheimer's disease (AD), are often associated with neurological symptoms. Clinical symptoms reflect the localization of the degenerative process rather than the nature of the underlying histopathology. Degeneration of the ...
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When patients present with a dementia syndrome at a young age, the experienced clinician will automatically include uncommon dementias in the diagnostic considerations, as familial uncommon dementias due to genetic mutations frequently present as early-onset dementias. This paper highlights why uncommon dementias due to genetic mutations, although marginal in terms of prevalence numbers in the ...
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ژورنال
عنوان ژورنال: European Journal of Medical and Health Sciences
سال: 2020
ISSN: 2593-8339
DOI: 10.24018/ejmed.2020.2.2.227